Proven, advanced long‑lasting relief6-8
Systane™ Hydration Preservative‑Free is designed to meet the needs of patients with persistent dry eye symptoms8. Systane™ Hydration’s dual‑polymer formulation provides 2x greater hydration & protection vs. HA alone3.
What makes Systane™ HYDRATION Preservative‑Free different?
Supports ocular surface healing and provides long‑lasting Dry Eye relief1-4. Combination of Hyaluronic Acid with HP‑Guar provides advanced hydration and symptom relief3.
Improved corneal re‑epithelialization1.
2x greater moisture retention vs HA alone3.
2x lubricity vs HA alone3.
Reduces Dry Eye symptoms in post‑surgical patients5.
Who is Systane™ HYDRATION Preservative‑Free suitable for?
Moderate – Chronic Dry Eye Sufferers
Patients with damaged ocular surface including peri‑operative Dry Eye (e.g., Cataract or
Lasik patients, trauma)
Contact lens wearers
Muco‑aqueous Dry Eye
How to use Systane™ HYDRATION
Preservative‑Free?
1. Wash and dry your hands. Shake the bottle well before first opening
2. Tilt your head back and gently pull your eyelid to form a pocket
3. Gently squeeze the bottle to allow 1 drop into the pocket. Keep the tip of the bottle untouched
4. Blink several times. Suitable for use with soft contact lenses.
Proven, advanced long‑lasting Dry Eye relief1-4
Designed to meet the needs of patients with persistent symptoms
Dual‑polymer formula provides 2X greater hydration and protection vs. HA alone1
Significantly longer tear film stability vs 0.1% HA & 0.2% HA only formulations2
Provides superior healing and corneal re‑epitheliazation3 vs. other HA containing artificial tears
96% of patients rated their experience with Systane® HYDRATION as rather or fully satisfied4
HA: Hyaluronic Acid. HP‑Guar: Hydroxypropyl‑guar.
* Compared to HA‑only formulation. † Tear breakup time for 0.15% HA‑HPG vs. 0.2% HA & 0.1%
HA eye drops (10.3 ± 6.5 vs. 7.7 ± 3.6 and 7.5 ± 4.1; post hoc p=0.01 and p=0.003). In this
clinical study (Australia) 0.1% HA (Hydro Fresh) has been used as a competitor product. ‡ In
vitro data. Mouse corneal model (Re‑epithelialization) vs Optive Fusion (p=0.0001); Vismed
(p=0.0001); Thealoz Duo (p=0.0016); Hyabak (p=0.0001); Hylo‑Comod (p=0.0369). § The
calculation made of 38% rather agreed and 58% absolutely agreed to say Systane™ HYDRATION
MDPF is a satisfying product to manage eye dryness. Survey conducted in Italy and Spain (N=
2,529 patients) (May 2021‑Jan 2022).
Consult your healthcare or eye care professional for use, precautions, warnings and
contraindications.
1. Carlson E, Kao WWY, Ogundele A. Impact of hyaluronic acid‑containing artificial tear
products on reepithelialization in an in vivo corneal wound model. J Ocul Pharmacol Ther.
2018;34(4):360‑364.
2. Davitt WF, Bloomenstein M, Christensen M, Martin AE. Efficacy in patients with dry eye
after treatment with a new lubricant eye drop formulation. J Ocul Pharmacol Ther.
2010;26(4):347‑353.
3. Rangarajan R, Kraybill B, Ogundele A, Ketelson HA. Effects of a hyaluronic
acid/hydroxypropyl guar artificial tear solution on protection, recovery, and lubricity in
models of corneal epithelium. J Ocul Pharmacol Ther. 2015;31(8):491‑497.
4. Christensen MT, Cohen S, Rinehart J, et al. Clinical evaluation of an HP‑Guar gellable
lubricant eye drop for the relief of dryness of the eye. Curr. Eye Res.
2004;28(1):55‑62.
5. Srinivasan S, Manoj V. A Decade of Effective Dry Eye Disease Management with Systane
Ultra (Polyethylene Glycol/Propylene Glycol with Hydroxypropyl Guar) Lubricant Eye Drops.
Clin Ophthalmol. 2021;15:2421‑2435.
6. Davitt WF, J Ocul Pharmacol Ther. 2010;26(4):347‑353.
7. Rolando M, J Ocul Pharmacol Ther. 2009;25(3):271‑278.
8. Srinivasan S, Garofalo R, Williams R. Clin Ophthalmol. 2023 Dec 13;17:3883‑3898.